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KMID : 0363320060270030617
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Journal of Korean Oriental Internal Medicine
2006 Volume.27 No. 3 p.617 ~ p.628
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Effects of Kamibangpungtongsungsan on Hypertension in Spontaneous Hypertensive Rats Fed a Hyperlipidemic Diet
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Kim Jong-Won
Jo Hyun-Kyung
Yoo Ho-Rhyong
Seol In-Chan
Kim Yoon-Sik
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Abstract
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This experiment was performed to determine the effects of Kamibangpungtongsungsan on hypertension in spontaneous hypertensive rats fed a hyperlipidemic diet (H-SHR). The results are summarized as follows : 1. Kamibangpungtongsungsan significantly decreased the blood pressure and pulse of rats in H-SHR. 2. Kamibangpungtongsungsan significantly decreased the levels of Aldosterone in H-SHR. 3. Kamibangpungtongsungsan significantly decreased the levels of dopamine and epinephrine in H-SHR, but did not significantly reduce the levels of norepinephrine, in H-SHR. 4. Kamibangpungtongsungsan did not significantly reduce the levels of electrolytes in H-SHR. 5. Kamibangpungtongsungsan significantly decreased the TNF- and IL-6 levels in H-SHR but the IL-10 level increase no significant. These results suggest that the Kamibangpungtongsungsan might be usefully applied for the treatment of hypertension with hyperlipidemia.
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KEYWORD
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Kamibaugpungtongsungsan, hypertension, catecholamine, cytokine
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